The effects of tobacco smoke exposure on caffeine metabolism

Caffeine and nicotine are some of the most often self-administered substances worldwide. Very often they are taken simultaneously and it seems that this fact is correlated with the amount of caffeine and nicotine administered. The aim of this study is to determine, whether tobacco smoke influences the metabolism of caffeine. The secondary task is to establish whether caffeine has an effect on elimination of cotinine, nicotine’s main metabolite. The results showed that tobacco smoke influences the metabolism of caffeine by accelerating its elimination, by the means of induced CYP1A2 activity. As far as cotinine is concerned, no influence of caffeine on its elimination was observed.