Role of diffusion-weighted magnetic resonance (MR) imaging in differentiation between graves disease and painless thyroiditis

Background: To assess the role of diffusion-weighted MR imaging in differentiation between Graves' disease and painless thyroiditis. Material/Methods: A prospective study was conducted among 37 consecutive patients with untreated thyrotoxicosis (25 female and 12 male; mean age of 44 years) and 15 age- and sex-matched controls. Diffusion-weighted MR imaging of the thyroid gland was performed in patients and controls. The apparent diffusion coefficient (ADC) value of the thyroid gland was calculated and correlated with Tc-99m uptake and thyroid function tests of the patients. Results: There was a significant difference in the ADC value of the thyroid gland between patients and the control group (P=0.001). The mean ADC value of the thyroid gland in Graves' disease was 2.03±0.28×10-3 mm2/sec, and in patients with painless thyroiditis 1.46±0.22×10-3 mm2/sec, respectively. There was a significant difference in the ADC values between Graves' disease and painless thyroiditis (P=0.001). When the ADC value of 1.45×10-3 mm2/sec was used as a threshold value for differentiating Graves' disease from painless thyroiditis, the best result was obtained with area under the curve of 0.934, accuracy of 83.8%, sensitivity of 95.8%, and specificity of 61.5%. The mean ADC value of the thyroid gland in patients positively correlated with serum TRAb and Tc-99m uptake (r=0.57, P=0.001 and r=0.74, P=0.001, respectively). Conclusions: We concluded that ADC values of the thyroid gland can be used to differentiate Graves' disease from painless thyroiditis in patients with untreated thyrotoxicosis.