Effects of vanadium complexes supplementation on V, Cu, Mn, K, Fe, Zn, and Ca concentration in STZ diabetic rats pancreas

The objective of the study was to assess the effects of Na[V V O(O 2 ) 2 (2,2í-bpy)] ◊ 8 H 2 O (complex 1), Na[V V O(O 2 ) 2 (1,10í-phen)] ◊ 5 H 2 O (complex 2 ), Na[V V O(O 2 ) 2 (4,4í-Me-2,2í-bpy)] ◊ 8 H 2 O (complex 3 ), [ V IV O(SO 4 )(1,10í-phen)] ◊ 2 H 2 O, (complex 4 ), [ V IV O(SO 4 )(2,2í-bpy)] ◊ H 2 O (complex 5 ), where: 2,2í-bpy = 2,2í-bipyridine, 1,10í-phen = 1,10í-phenanthroline, 4,4í-Me-2,2í-bpy = 4,4í-dimethyl-2,2í-bipyridine and a small insulin injection on V, Cu, Mn, K, Fe, Zn, and Ca concentration in the STZ (streptozotocin) diabetic rats pancreas during a 5-week treatment with the tested complexes. In all groups of animals metal concentration in the pancreas was investigated by means of Proton Induced X-ray Emission (PIXE) method. Maximum con- centration of vanadium was observed in the pancreas for complex 5 (1.69 ± 0.09 mg/kg dry weight), lower for complex 3 (1.51 ± 0.10 mg/kg dry weight), and the lowest for complex 1 (1.21 ± 0.27 mg/kg dry weight) sup- plementation. The influence of vanadium administration on other metalsí concentration in the ratsí pancreas was also investigated. All vanadium-tested complexes showed an increase of zinc concentration in the exam- ined pancreas in comparison to the diabetic animals not treated with vanadium. The results were the highest for complex 1 and the lowest for complex 5. The concentration of Fe, Cu, Mn, K and Ca in the pancreas is not evi- dently influenced by administration of the vanadium complexe.