- Tytuł:
- Hepatoselective nitric oxide (NO) donors, V-PYRRO/NO and V-PROLI/NO, in nonalcoholic fatty liver disease : a comparison of antisteatotic effects with the biotransformation and pharmacokinetics
- Autorzy:
-
Keefer, Larry K.
Kij, Agnieszka
Zabielski, Piotr
Chabowski, Adrian
Zakrzewska, Agnieszka
Maślak, Edyta
Gonciarz-Dytman, Anna
Sitek, Barbara
Walczak, Maria
Saavedra, Joseph E.
Holland, Ryan J.
Chłopicki, Stefan
Wandzel, Krystyna
Kuś, Kamil - Data publikacji:
- 2015
- Słowa kluczowe:
-
drug disposition
male
mean residence time
ex vivo study
Mus
drug binding site
cytochrome P450 2E1
mouse
controlled study
enzyme activity
unclassified drug
animal model
antisteatotic activity
drug absorption
drug efficacy
drug elimination
nonalcoholic fatty liver
nonhuman
in vivo study
drug excretion
glucose tolerance
2-diolate
drug metabolism
drug distribution
liver protection
o 2 vinyl [2 (carboxylato)pyrrolidin 1 yl]diazen 1 ium 1
drug uptake
drug bioavailability
liver protective agent
drug activity
cytochrome P450 1A2
Murinae
o 2 vinyl 1 (pyrrolidin 1 yl)diazen 1 ium 1
rat
insulin resistance
lipid composition
cytochrome P450 3A4
animal tissue
drug structure
maximum plasma concentration
priority journal
cytochrome P450 2C9
animal cell
time to maximum plasma concentration
area under the curve
animal experiment
article
binding affinity - Pokaż więcej
- Dostawca treści:
- Repozytorium Uniwersytetu Jagiellońskiego
Artykuł