- Tytuł:
- Hepatoselective nitric oxide (NO) donors, V-PYRRO/NO and V-PROLI/NO, in nonalcoholic fatty liver disease : a comparison of antisteatotic effects with the biotransformation and pharmacokinetics
- Autorzy:
-
Kij, Agnieszka
Holland, Ryan J.
Chabowski, Adrian
Zabielski, Piotr
Kuś, Kamil
Gonciarz-Dytman, Anna
Sitek, Barbara
Chłopicki, Stefan
Saavedra, Joseph E.
Wandzel, Krystyna
Zakrzewska, Agnieszka
Keefer, Larry K.
Maślak, Edyta
Walczak, Maria - Data publikacji:
- 2015
- Słowa kluczowe:
-
area under the curve
liver protection
lipid composition
cytochrome P450 1A2
liver protective agent
maximum plasma concentration
mouse
nonalcoholic fatty liver
Mus
binding affinity
in vivo study
nonhuman
drug absorption
drug elimination
male
Murinae
animal experiment
antisteatotic activity
cytochrome P450 3A4
mean residence time
o 2 vinyl 1 (pyrrolidin 1 yl)diazen 1 ium 1
drug binding site
ex vivo study
drug distribution
2-diolate
drug metabolism
drug uptake
rat
article
controlled study
drug excretion
enzyme activity
drug structure
unclassified drug
animal cell
glucose tolerance
cytochrome P450 2E1
animal model
drug activity
drug bioavailability
o 2 vinyl [2 (carboxylato)pyrrolidin 1 yl]diazen 1 ium 1
time to maximum plasma concentration
drug disposition
cytochrome P450 2C9
drug efficacy
priority journal
animal tissue
insulin resistance - Pokaż więcej
- Dostawca treści:
- Repozytorium Uniwersytetu Jagiellońskiego
Artykuł