- Tytuł:
- Hepatoselective nitric oxide (NO) donors, V-PYRRO/NO and V-PROLI/NO, in nonalcoholic fatty liver disease : a comparison of antisteatotic effects with the biotransformation and pharmacokinetics
- Autorzy:
-
Holland, Ryan J.
Gonciarz-Dytman, Anna
Zakrzewska, Agnieszka
Chabowski, Adrian
Chłopicki, Stefan
Saavedra, Joseph E.
Sitek, Barbara
Zabielski, Piotr
Kij, Agnieszka
Keefer, Larry K.
Maślak, Edyta
Kuś, Kamil
Wandzel, Krystyna
Walczak, Maria - Data publikacji:
- 2015
- Słowa kluczowe:
-
drug disposition
liver protective agent
enzyme activity
animal experiment
animal tissue
controlled study
mean residence time
male
priority journal
o 2 vinyl 1 (pyrrolidin 1 yl)diazen 1 ium 1
liver protection
in vivo study
drug metabolism
Mus
cytochrome P450 3A4
2-diolate
cytochrome P450 2C9
rat
o 2 vinyl [2 (carboxylato)pyrrolidin 1 yl]diazen 1 ium 1
article
ex vivo study
drug uptake
glucose tolerance
drug distribution
unclassified drug
drug binding site
Murinae
binding affinity
area under the curve
drug efficacy
insulin resistance
mouse
nonhuman
time to maximum plasma concentration
cytochrome P450 1A2
drug excretion
antisteatotic activity
drug absorption
drug elimination
cytochrome P450 2E1
animal cell
animal model
lipid composition
maximum plasma concentration
nonalcoholic fatty liver
drug structure
drug activity
drug bioavailability - Pokaż więcej
- Dostawca treści:
- Repozytorium Uniwersytetu Jagiellońskiego
Artykuł