- Tytuł:
- Markers of lipid peroxidation and antioxidant status in the serum and saliva of patients with active Crohn disease
- Autorzy:
-
Krzyściak, Wirginia
Pytko-Polończyk, Jolanta
Mach, Tomasz
Domagała-Rodacka, Renata
Cibor, Dorota
Szczeklik, Katarzyna
Owczarek, Danuta - Data publikacji:
- 2018
- Słowa kluczowe:
-
Increased oxidative stress has been implicated in the pathogenesis of Crohn disease
(CD). Except for C‑reactive
protein (CRP), good biological markers of CD activity are lacking. We aimed to investigate the diagnostic usefulness of selected markers of oxidative stress
in the serum and saliva of patients with active and inactive CD. A total of 58 patients with confirmed CD (32 with active CD, 26 with inactive CD,
and 26 healthy controls) were prospectively enrolled to the study. The markers examined were malondialdehyde
(MDA), ferric reducing ability of plasma (FRAP), reduced glutathione (GSH), and catalase (CAT). MDA levels were higher in the serum and saliva of patients with active CD than in those with
inactive CD and controls and were positively correlated with the Crohn’s Disease Activity Index (r =
0.8, P <0.001) and CRP (P <0.001). Serum and saliva antioxidant indicators (FRAP and GSH) were
decreased in both CD groups compared with controls and were negatively correlated with clinical activity
and inflammation (FRAP, r = -0.5, P <0.001; GSH, r = -0.5, P <0.001; and CAT, r = -0.5, P <0.001). The increased lipid peroxidation and decreased antioxidant activity in serum and saliva
confirm that CD patients are under oxidative stress. The positive correlations of MDA with the clinical
activity and inflammation, as well as the comparison of the receiver operating characteristic curves for
MDA and CRP, suggest that MDA could be a good diagnostic marker of CD.
lipid peroxidation
serum
saliva
Crohn disease - Pokaż więcej
- Dostawca treści:
- Repozytorium Uniwersytetu Jagiellońskiego
Artykuł