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Wyświetlanie 1-4 z 4
Tytuł:
Metagenomic analysis of duodenal microbiota reveals a potential biomarker of dysbiosis in the course of obesity and type 2 diabetes : a pilot study
Autorzy:
Major, Piotr
Salamon, Dominika
Bulanda, Małgorzata
Stanek, Maciej
Gosiewski, Tomasz
Sroka-Oleksiak, Agnieszka
Młodzińska, Agata
Data publikacji:
2020
Słowa kluczowe:
type 2 diabetes
next-generation sequencing (NGS)
duodenal microbiota
bifidobacterium
obesity
Numerous scientific studies confirm that, apart from environmental and genetic factors, a significant role is played by gastrointestinal microbiota in the aetiology of type 2 diabetes and obesity. Currently, scientists mainly focus on the distal intestinal microbiota, while the equally important proximal parts of the intestine are overlooked. The aim of the study was a qualitative analysis of the structure of the duodenal mucosa microbiota in groups of patients with obesity and with type 2 diabetes and where obesity qualified for bariatric surgery: sleeve gastrectomy. The microbiological results obtained were compared with some clinical parameters. As a result, it was possible to determine the microbiological core that the treatment and control groups had in common, including phyla: Firmicutes, Proteobacteria, and Actinobacteria. The patients with obesity and with type 2 diabetes and obesity presented a significantly lower number of genus Bifidobacterium compared to healthy subjects. Furthermore, the numbers of Bifidobacterium were positively correlated with the high density lipoprotein (HDL) concentration in the groups under study. The obtained results indicate that bacteria of the genus Bifidobacterium should be considered in the future in the context of a potential biomarker in the progress of type 2 diabetes and obesity.
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Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
Tytuł:
Relation between adipose tissue and the musculoskeletal unit in a group of postmenopausal women
Autorzy:
Warzecha, Maja
Madejska, Natalia
Amarowicz, Jarosław
Data publikacji:
2022
Słowa kluczowe:
Introduction Involutional changes observed during aging increase rapidly in the postmenopausal period. These changes include body composition by affecting bone
p < 0.001). The results were not supported by muscle strength (handgrip). The authors identified correlations between the bone parameters and adipose tissue but these were identified as weak or moderate (p < 0.05). Special emphasis should be placed on the relation between the trabecular bone score (TBS) and VAT area (r = –0.385
SD 5.3). All women had been asked to complete a questionnaire (medical history) and underwent a total body composition analysis [bone mineral density (BMD)] testing (spine and/or neck) followed by a handgrip test. Results The study revealed strong correlations between appendicular skeletal muscle mass index – appen.lean/height2
muscle and fat tissue. A number of studies have investigated the mutual interaction between bone and muscle tissue
p < 0.001). Conclusions There is a strong dependence between muscle and adipose tissues. Despite the fact that the increase in fat is correlated with the growth of muscle tissue
it is not accompanied by better quality of the muscle (handgrip). Bone microarchitecture is more related to VAT area than neck/spine BMD.
visceral adipose tissue area (VAT) and fat/mass/height2 index (r = 0.589 and 0.658 respectively
whereas adipose tissue had not been studied thoroughly. The aim of the present study was to assess the relation between fat tissue parameters and the musculoskeletal unit. Material and methods The study was conducted in a group of 120 postmenopausal women with an average age of 69 years (59–81
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Dostawca treści:
Repozytorium Uniwersytetu Jagiellońskiego
Artykuł
    Wyświetlanie 1-4 z 4

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